Activation of pancreatic B-cell genes by multiplex epigenetic CRISPR-editing
Carla Alejandra Giménez, Lucía A. Curti, Sung-Ho Hyon, G.L. Farfalli Luis, Pablo J. Ross, Federico Pereyra-Bonnet
This study uses CRISPR-based epigenetic editing to activate pancreatic beta-cell genes in human cells, showing that sequential activation of transcription factors is more effective than simultaneous activation.
bioRxiv · Jul 24, 2020 · PreprintMolecular Biology