Pablo J. Ross

Epigenetic Remodeling Increases Plasticity of Bovine Fibroblasts Without Improving Embryo and Stem Cell Development

This study evaluates a multi-target small-molecule cocktail, GUSTC, to reduce repressive heterochromatin marks in bovine fibroblasts, enhancing reprogramming potential without improving embryo development.

An integrated multi-tissue atlas of epigenomic landscapes and regulatory elements in the bovine genome

The paper constructs a bovine epigenomic atlas to annotate regulatory elements and decode the regulatory syntax of the cattle genome, aiding in fine-mapping GWAS loci for complex traits.

Efficient Generation of SOCS2 Knock-out Sheep by Electroporation of CRISPR-Cas9 Ribonucleoprotein Complex with Dual-sgRNAs.

This study generates SOCS2 knock-out sheep using CRISPR-Cas9 ribonucleoprotein electroporation, resulting in compound heterozygotes with large deletions and trace SOCS2 expression.

The Neonatal Gyrencephalic Cortex Maintains Regionally Distinct Streams of Neuroblasts

The paper identifies an expanded subventricular zone in neonatal gyrencephalic brains that supports ongoing neuronal migration to the cortex.

Functional genomics of cattle through integration of multi-omics data

The paper improves bovine genome annotation by integrating multi-omics data to identify novel transcripts and gene functions, and constructs a trait similarity network.

A comprehensive prediction of transcript isoforms in 19 chicken tissues by Oxford Nanopore long-read sequencing

The paper uses Oxford Nanopore long-read sequencing to annotate transcript isoforms in 19 chicken tissues, identifying novel transcripts and highlighting tissue-specific expression patterns.

Characterization of Histone Lysine β-hydroxybutyrylation in bovine tissues, cells, and cumulus-oocyte complexes

The paper investigates the effects of beta-hydroxybutyrate on histone lysine beta-hydroxybutyrylation and transcriptome changes in bovine fibroblasts and cumulus-oocyte complexes, showing altered gene expression but no impact on oocyte meiotic competence.

Resetting H3K4me3, H3K27ac, H3K9me3 and H3K27me3 during the maternal-to-zygotic transition and blastocyst lineage specification in bovine embryos

This study profiles histone modifications during bovine preimplantation development, showing their role in gene regulation and lineage specification.

Transcription initiation mapping in 31 bovine tissues reveals complex promoter activity, pervasive transcription, and tissue-specific promoter usage

This study maps transcription initiation sites in 31 bovine tissues, revealing promoter activity, pervasive transcription, and tissue-specific promoter usage comparable to human and mouse.

Interneuron origins in the embryonic porcine medial ganglionic eminence

This study shows that porcine embryonic medial ganglionic eminence progenitors develop into interneurons similar to rodents, supporting their use in xenotransplantation therapies.

A comparative analysis of chromatin accessibility in cattle, pig, and mouse tissues

The paper identifies and compares chromatin accessibility in cattle, pig, and mouse tissues using ATAC-seq, finding species-specific regulatory elements and conservation patterns.

Chromatin remodeling in bovine embryos indicates species-specific regulation of genome activation

The paper profiles accessible chromatin in bovine embryos to show species-specific regulation of genome activation, finding similarities between cattle and humans but differences from mice.

Activation of pancreatic B-cell genes by multiplex epigenetic CRISPR-editing

This study uses CRISPR-based epigenetic editing to activate pancreatic beta-cell genes in human cells, showing that sequential activation of transcription factors is more effective than simultaneous activation.

Catalytic inhibition of H3K9me2 writers disturbs epigenetic marks during bovine nuclear reprogramming.

This study inhibits EHMT1/2 with UNC0638 in bovine cells during reprogramming, reducing H3K9me2 and other marks but not improving preimplantation development.

Molecular and genetic regulation of pig pancreatic islet cell development

This study investigates pig pancreatic islet development, identifying similarities with human islet ontogeny and uncovering signaling pathways relevant to beta-cell maturation.