Author

Carla Alejandra Giménez

Caspr BiotechORCID 0000-0003-3532-0891Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:CRISPR screen· 1 Research Focus:perturbation response prediction· 1 Organism:virus· 1

Frequent Co-Authors

Federico Pereyra-Bonnet· 2 shared Lucía A. CurtiiD· 2 shared G.L. Farfalli Luis· 1 shared Pablo J. RossiD· 1 shared Sung-Ho Hyon· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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2 shared papersMolecular Biology

Federico Pereyra-Bonnet

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2 papers

Recent·Most cited

Activation of pancreatic B-cell genes by multiplex epigenetic CRISPR-editing

Carla Alejandra Giménez, Lucía A. Curti, Sung-Ho Hyon, G.L. Farfalli Luis, Pablo J. Ross, Federico Pereyra-Bonnet

This study uses CRISPR-based epigenetic editing to activate pancreatic beta-cell genes in human cells, showing that sequential activation of transcription factors is more effective than simultaneous activation.

bioRxiv · Jul 24, 2020 · PreprintMolecular Biology

An ultrasensitive, rapid, and portable coronavirus SARS-CoV-2 sequence detection method based on CRISPR-Cas12

Lucía A. Curti, Federico Pereyra-Bonnet, Carla Alejandra Giménez

Reverse-transcription recombinase polymerase amplification (RT-RPA) plus LbCas12a collateral cleavage detected synthetic SARS-CoV-2 ORF1ab RNA down to 10 copies/µL by fluorescence, with similar lateral-flow strip sensitivity.

bioRxiv · Feb 29, 2020 · PreprintMolecular Biology✦ In-depth digest