Canonical and noncanonical TGF-β signaling regulate fibrous tissue differentiation in the axial skeleton
Sade W. Clayton, Ga I Ban, Cunren Liu, Rosa A. Serra
This study shows TGF-β regulates fibrous tissue markers in sclerotome via both canonical Smad3 and noncanonical ERK1/2 pathways, with Scleraxis acting as an intermediate.
Scientific Reports · Dec 7, 2020Peer-reviewedDevelopmental Biology