Sade W. Clayton

A PDMS-based microfluidic platform enabling dual biochemical and electric-field stimulation for modeling sensory neuron-intervertebral disc crosstalk

This paper develops a microfluidic platform to model sensory neuron-intervertebral disc crosstalk by combining biochemical and electric-field stimulation.

The transcriptome and secreted factors of the intervertebral discs in STZ HFD Type2 diabetic male mice reveal extensive inflammation

This study examines the transcriptome and secreted factors in intervertebral discs of STZ-HFD T2D mice, revealing increased inflammation and degeneration compared to controls.

Single cell RNA sequencing reveals a shift in cell function and maturation of endogenous and infiltrating cell types in response to acute intervertebral disc injury

This study uses single-cell RNA sequencing to analyze changes in cell function and maturation in the intervertebral disc after injury, identifying key cell populations and pathways involved in degeneration.

VEGFA critically controls neurovascular invasion and chronic low back pain during intervertebral disc degeneration

This study shows that VEGFA drives neurovascular invasion in degenerating intervertebral discs and contributes to chronic low back pain, with its inhibition preventing pain behaviors.

Analysis of Infiltrating Immune Cells Following Intervertebral Disc Injury Reveals Recruitment of Gamma-Delta (????) T cells in Female Mice

This study identifies sex-specific immune cell responses following intervertebral disc injury, revealing differential recruitment of gamma-delta T cells in female mice and NKT cells in males.

TGFβ signaling is required for sclerotome resegmentation during development of the spinal column in Gallus gallus.

This study shows that TGFβ signaling is required for sclerotome resegmentation in chick embryos, leading to vertebral malformations and disrupted rostro-caudal patterning.

Canonical and noncanonical TGF-β signaling regulate fibrous tissue differentiation in the axial skeleton

This study shows TGF-β regulates fibrous tissue markers in sclerotome via both canonical Smad3 and noncanonical ERK1/2 pathways, with Scleraxis acting as an intermediate.