Deep mutational scanning reveals pharmacologically relevant insights into TYK2 signaling and disease
Conor J Howard, Nathan S. Abell, Robert Warneford-Thomson, Eden Mahdavi, Alan L Su, Carmen Resnick, Nabil Mohammed, Erin M. Thompson, Emily Rose Holzinger, Katrina A. Catalano, Abhay Hukku, Gabriel A. Mintier, Morgan MacKenzie, Bryan L. Jiang, Dora Barbosa Rabago, , Diane E. Dickel
This study uses deep mutational scanning to analyze TYK2 variants and their impact on function and drug response, identifying novel therapeutic targets and degradation strategies.
eLife · Jun 10, 2026Peer-reviewedGenomics