Multimodal dynamics control activity of a glial glutamate transporter
Qianyi Wu, Didar Ciftci, Juan Carlos Canul-Tec, Nicolás Reyes, Gabriel Glenn Gregorio, Yun T. Huang, Olga Boudker
This study uses a combined experimental platform to analyze the conformational dynamics of EAAT1, revealing that multimodal dynamics regulate its function and identifying a mutation that inhibits transport by stabilizing a paused conformation.
bioRxiv · Jun 2, 2026 · PreprintBiophysics