Olga Boudker

This study uses a combined experimental platform to analyze the conformational dynamics of EAAT1, revealing that multimodal dynamics regulate its function and identifying a mutation that inhibits transport by stabilizing a paused conformation.

This study determines the cryo-EM structure of SLC1A1 bound to an inhibitor, identifies its binding mechanism, and develops improved inhibitors with enhanced cytotoxicity in kidney cancer cells.

This study determines the cryo-EM structures of EAAT3 bound to different substrates, revealing how conformational changes and sodium binding influence substrate recognition and transport.