5-hydroxymethylcytosine deposition mediates Polycomb Repressive Complex 2 function in MYCN-amplified neuroblastoma
Mohansrinivas Chennakesavalu, Gabriel L. Lopez, Varsha Gupta, Kelley Moore, Yuqing Xue, Adam L. Handen, Josie Majowka, Sahil Veeravalli, Ryan Borchert, Monica M. Pomaville, Alexandre Chlenski, Chuan He, Andrea Piunti, Mark A. Applebaum
This study shows that 5-hydroxymethylcytosine (5-hmC) and H3K27me3 co-localize on PRC2 target genes in MYCN-amplified neuroblastoma, repressing developmental genes and sensitizing tumors to DNA demethylating agents.
iScience · Jul 16, 2026Peer-reviewedCancer Biology