Mark A. Applebaum

The paper develops NB-PathAssist, a computational framework for automated classification of peripheral neuroblastic tumors using whole-slide histology images, achieving high accuracy in prognostic grouping.

This study shows that 5-hydroxymethylcytosine (5-hmC) and H3K27me3 co-localize on PRC2 target genes in MYCN-amplified neuroblastoma, repressing developmental genes and sensitizing tumors to DNA demethylating agents.

This study shows histotripsy enhances chemotherapy effectiveness in a neuroblastoma mouse model by inducing a systemic immune response and altering the tumor microenvironment.

The paper identifies bivalent genes in neuroblastoma cell-free DNA associated with poor prognosis in high-risk patients.

The paper identifies adrenergic and mesenchymal signatures in cell-free DNA 5-hmC profiles and shows their correlation with metastatic burden in neuroblastoma patients.