Author

Alexandre Chlenski

University of ChicagoORCID 0000-0002-9885-4017Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:DNA methylation· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Chuan HeiD· 3 shared Kelley MooreiD· 3 shared Mark A. ApplebaumiD· 3 shared Mohansrinivas ChennakesavaluiD· 3 shared Andrea PiuntiiD· 2 shared Gepoliano S. ChavesiD· 2 shared Rachel TerHaar· 2 shared Sahil VeeravalliiD· 2 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersGenomics

Chuan HeORCID

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Author profile →

3 papers

Recent·Most cited

5-hydroxymethylcytosine deposition mediates Polycomb Repressive Complex 2 function in MYCN-amplified neuroblastoma

Mohansrinivas Chennakesavalu, Gabriel L. Lopez, Varsha Gupta, Kelley Moore, Yuqing Xue, Adam L. Handen, Josie Majowka, Sahil Veeravalli, Ryan Borchert, Monica M. Pomaville, Alexandre Chlenski, Chuan He, Andrea Piunti, Mark A. Applebaum

This study shows that 5-hydroxymethylcytosine (5-hmC) and H3K27me3 co-localize on PRC2 target genes in MYCN-amplified neuroblastoma, repressing developmental genes and sensitizing tumors to DNA demethylating agents.

iScience · Jul 16, 2026Peer-reviewedCancer Biology

5-hydroxymethylcytosine profiling of cell-free DNA identifies bivalent genes that are prognostic of survival in high-risk neuroblastoma.

Mohansrinivas Chennakesavalu, Kelley Moore, Gepoliano S. Chaves, Sahil Veeravalli, Rachel TerHaar, Tong Wu, Ruitu Lyu, Alexandre Chlenski, Chuan He, Andrea Piunti, Mark A. Applebaum

The paper identifies bivalent genes in neuroblastoma cell-free DNA associated with poor prognosis in high-risk patients.

JCO Precision Oncology · Jan 31, 2024Peer-reviewedGenomics

Adrenergic and mesenchymal signatures are identifiable in cell-free DNA and correlate with metastatic disease burden in children with neuroblastoma

Omar R. Vayani, Maria E. Kaufman, Kelley Moore, Mohansrinivas Chennakesavalu, Rachel TerHaar, Gepoliano S. Chaves, Alexandre Chlenski, Chuan He, Susan Lerner Cohn, Mark A. Applebaum

The paper identifies adrenergic and mesenchymal signatures in cell-free DNA 5-hmC profiles and shows their correlation with metastatic burden in neuroblastoma patients.

Pediatric Blood & Cancer · Oct 20, 2023Peer-reviewedGenomics