Combined Lineage Tracing and scRNA-seq Reveals Unexpected First Heart Field Predominance of Human iPSC Differentiation
Francisco X. Galdos, Carissa Lee, Soah Lee, Sharon L. Paige, William Rowland Goodyer, Sidra Xu, Tahmina Samad, Gabriela V Escobar, Adrija K. Darsha, Aimee Beck, Rasmus Otkjær Bak, Matthew Hebden Porteus, Sean M. Wu
The paper uses lineage tracing and scRNA-seq to show that human iPSC differentiation predominantly generates left ventricular cardiomyocytes from the first heart field.
eLife · Jun 5, 2023Peer-reviewedDevelopmental Biology