Sean M. Wu

This study investigates factors influencing HCM phenotype penetrance by comparing MYH7 mutations in isogenic hiPSC-CMs and shows that beta-adrenergic stimulation and gene dosage affect disease expression.

This study identifies CXCR3-CXCL9/10 axis as a therapeutic target for ICI-mediated myocarditis using mouse models and human patient data.

This study investigates the effects of the MYH7 G256E mutation on myosin function across multiple scales, finding increased hypercontractility and mitochondrial respiration.

The paper uses lineage tracing and scRNA-seq to show that human iPSC differentiation predominantly generates left ventricular cardiomyocytes from the first heart field.

This study identifies KMT2D-NOTCH signaling defects in HLHS coronary artery endothelial cells, showing impaired differentiation and proliferation due to suppressed NOTCH target genes.

This study identifies sequential defects in cardiac lineage commitment and maturation in hypoplastic left heart syndrome using multi-omics approaches and iPSC modeling.

This study uses single-cell RNA sequencing to identify endocardial defects in hypoplastic left heart syndrome, linking them to abnormal valve and septum development.

The paper uses transcriptomic data to identify potential drug therapies for a monogenic disease by finding FDA-approved drugs with similar transcriptional profiles.