Author

Soah Lee

Sungkyunkwan UniversityORCID 0000-0001-7613-592XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Approach:experimental assay· 1

Frequent Co-Authors

Sean M. WuiD· 3 shared Alison Schroer Vander RoestiD· 2 shared Brock RobertsiD· 2 shared Carissa LeeiD· 2 shared Daniel BernsteiniD· 2 shared James W.S. JahngiD· 2 shared Joseph C. WuiD· 2 shared Paul V. HeinrichiD· 2 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersMolecular Biology

Sean M. WuORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Molecular BiologybioRxivPreprintJun 6, 2026

Beta-Adrenergic Stimulation and MYH7 G256E Mutant Gene Dosage Drive Hypertrophic Cardiomyopathy Phenotype Penetrance

Paul V. Heinrich, Raina M. Jung, Jonathan Samuel Achter…·Sean M. Wu

This study investigates factors influencing HCM phenotype penetrance by comparing MYH7 mutations in isogenic hiPSC-CMs and shows that beta-adrenergic stimulation and gene dosage affect disease expression.

DOI 10.64898/2026.06.02.729411

humanbulk RNA-seq

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Molecular BiologybioRxivPreprintJun 8, 2023

Multi-scale models reveal hypertrophic cardiomyopathy MYH7 G256E mutation drives hypercontractility and elevated mitochondrial respiration

Soah Lee, Alison Schroer Vander Roest, Cheavar A. Blair…·Daniel Bernstein

This study investigates the effects of the MYH7 G256E mutation on myosin function across multiple scales, finding increased hypercontractility and mitochondrial respiration.

2 citations

humanscRNA-seq

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Developmental BiologyeLifePeer-reviewedJun 5, 2023

Combined Lineage Tracing and scRNA-seq Reveals Unexpected First Heart Field Predominance of Human iPSC Differentiation

Francisco X. Galdos, Carissa Lee, Soah Lee…·Sean M. Wu

The paper uses lineage tracing and scRNA-seq to show that human iPSC differentiation predominantly generates left ventricular cardiomyocytes from the first heart field.

49 citationstop 3%

humanscRNA-seq

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