Lineage-selective suicide gene system enables post-engraftment editing of cell therapy composition
Jennifer Jin, Chiara Pavan, Niamh Moriarty, Dmitry A. Ovchinnikov, Gabriella Farrell, Andrew T Quattrocchi, Cameron PJ Hunt, Clare L. Parish
The paper introduces NeuroGuard, a suicide gene system that selectively eliminates non-neuronal cells after transplantation, enhancing the safety and predictability of cell therapies.
bioRxiv · Jun 8, 2026 · PreprintNeuroscience