Dmitry A. Ovchinnikov

This study investigates SYNGAP1 haploinsufficiency in human patient-derived models, showing disrupted early neurodevelopment and accelerated neuronal maturation.

The paper introduces NeuroGuard, a suicide gene system that selectively eliminates non-neuronal cells after transplantation, enhancing the safety and predictability of cell therapies.

The paper uses machine learning to analyze neuronal morphology in Parkinson's disease iPSC-derived neurons, identifying genotype-specific mitochondrial and lysosomal abnormalities.

This study compares dopamine and cortical neurons with PD mutations to identify cellular dysfunctions linked to different pathological phenotypes.