Interplay between ferroptosis and guttae in an early-onset murine model of Fuchs endothelial corneal dystrophy (FECD)
Karin W. Handel, Jaegook Lim, Hiroko Iwashita, Sabina Khan, Hanna Shevalye, Sangwan Park, Nayeli Echeverria, Michelle Ferneding, Meher J. Khan, Karolina P. Roszak, Gabriella L. Donovan, 岩本真子, Jaeho Shim, Laura J. Young, Monica Ardon, , Sara M. Thomasy
This study shows that ferroptosis is linked to guttae formation in a murine model of Fuchs endothelial corneal dystrophy, providing a model for testing ferroptosis-targeted therapies.
bioRxiv · Jul 10, 2026 · PreprintDevelopmental Biology