Brian C. Leonard

This study establishes normative green autofluorescence (GAF) values in rhesus macaques across different retinal regions and links GAF to age, intraocular pressure, and retinal structure.

This study shows that ferroptosis is linked to guttae formation in a murine model of Fuchs endothelial corneal dystrophy, providing a model for testing ferroptosis-targeted therapies.

This paper investigates TAZ deficiency in a mouse model of FECD, identifying ER stress, mitochondrial dysfunction, and altered ECM organization as key pathogenic mechanisms.

This study uses intravital imaging to show corneal endothelial cells can regenerate in mice, and develops a therapeutic approach using modified mRNA to stimulate regeneration in aged mice.

This study shows that Arap1 in retinal pigment epithelium (RPE) is essential for photoreceptor survival through its role in phagocytosis, as Arap1 deficiency leads to photoreceptor degeneration.