Sara M. Thomasy

This study establishes normative green autofluorescence (GAF) values in rhesus macaques across different retinal regions and links GAF to age, intraocular pressure, and retinal structure.

The paper maps tubulin isotype localization during corneal development in chick embryos, revealing dynamic patterns and conserved spatial organization.

This study evaluates the safety and efficacy of AAV-mediated TYR gene augmentation in nonhuman primates for OCA1 treatment, showing localized hypermelanosis and RPE transduction without severe adverse effects.

This study shows that ferroptosis is linked to guttae formation in a murine model of Fuchs endothelial corneal dystrophy, providing a model for testing ferroptosis-targeted therapies.

This study uses 3D imaging and quantitative analysis to show how corneal endothelial cells maintain a regular monolayer structure despite dynamic tissue growth and mechanical strain.

This paper investigates TAZ deficiency in a mouse model of FECD, identifying ER stress, mitochondrial dysfunction, and altered ECM organization as key pathogenic mechanisms.

This study uses intravital imaging to show corneal endothelial cells can regenerate in mice, and develops a therapeutic approach using modified mRNA to stimulate regeneration in aged mice.

The paper shows that Zfp503 is essential for RPE differentiation and optic fissure closure, with loss of function leading to uveal coloboma and altered gene expression in developing mouse eyes.

This study examines age-related changes in rhesus macaque eyes and compares them to human age-related eye diseases, finding similarities in intraocular pressure, retinal structure, and macular lesions.

This study examines immune responses to AAV8 delivery via suprachoroidal route in nonhuman primates, finding mild inflammation and immune cell infiltration with reduced systemic viral capsid antibody responses.