Neuroinflammation characterizes the earliest changes in Alzheimer's disease pathology and associated subjective cognitive impairment in adult hydrocephalus biopsies
Wenrui Huang, Anne Marie W. Bartosch, Harrison Xiao, Xena E. Flowers, Sandra Leskinen, Zeljko Tomljanovic, Gail M. Iodice, Deborah M. Boyett, Eleonora F. Spinazzi, Vilas Menon, Robert A. McGovern, Guy M. McKhann, Andrew F. Teich
The paper identifies gene expression changes in Alzheimer's disease pathology linked to cognitive impairment in hydrocephalus biopsies, showing microglial activation and loss of homeostatic genes.
bioRxiv · Oct 1, 2020 · PreprintNeuroscience