Sandra Leskinen

This study shows that IDH1-mutant glioma cells are more sensitive to cysteine-methionine deprivation and ferroptosis inducers, and that IDH inhibitors enhance this sensitivity.

The paper evaluates how pre-sequencing RNA quality metrics (PMI and RIN) correlate with post-sequencing RNA quality metrics and gene expression in human brain tissue.

The paper analyzes bulk RNA-seq data from diverse ethnic groups to identify differentially expressed genes and pathways in Alzheimer's Disease, highlighting cross-ethnic and ethnic-specific findings.

The paper identifies six genetic loci associated with Alzheimer's disease in Hispanics, showing both genetic and epigenetic risks, with some downstream effects on mRNA expression being ethnicity-specific.

The paper identifies gene expression changes in Alzheimer's disease pathology linked to cognitive impairment in hydrocephalus biopsies, showing microglial activation and loss of homeostatic genes.