Author

Xena E. Flowers

Columbia University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 6

Signature Assays, Organisms & Methods

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Organism:human· 6 Approach:statistical model· 6 Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Assay:scRNA-seq· 3 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Vilas MenoniD· 5 shared Andrew F. TeichiD· 4 shared Elizabeth M. BradshawiD· 3 shared Serge PrzedborskiiD· 3 shared Estela Área-GómeziD· 2 shared Fahad ParyaniiD· 2 shared James E. GoldmaniD· 2 shared Jean Paul Vonsattel· 2 shared

Activity by Year

2020-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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5 shared papersNeuroscience

Vilas MenonORCID

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6 papers

Recent·Most cited

The spatial landscape of glial pathology and T-cell response in Parkinson's disease substantia nigra

Maxwell Ma, Fahad Paryani, Kelly A. Jakubiak, Shengnan Xia, Susumu Antoku, Adithya Kannan, Jaeseung Lee, Nacoya Madden, Shailesh Senthil Kumar, Juncheng Li, David Chen, Gunnar Hargus, Aayushi Mahajan, Xena E. Flowers, Ashley S. Harms, , Osama Al‐Dalahmah

The paper analyzes T-cell responses and glial pathology in Parkinson's disease substantia nigra using single nucleus RNA sequencing and spatial transcriptomics, revealing CD8+ T-cell characteristics and altered cellular interactions.

Nature Communications · Aug 4, 2025Peer-reviewedNeuroscience

Single-cell transcriptomic landscape of the neuroimmune compartment in amyotrophic lateral sclerosis brain and spinal cord

John F. Tuddenham, Masashi Fujita, Emily Lee, Nivedita Nimmagadda, Anthony Khairallah, Claire Harbison, Xena E. Flowers, Guillermo Coronas‐Samano, Silas Maniatis, Aidan C. Daly, Julie A. Schneider, Andrew F. Teich, Jean Paul Vonsattel, Peter A. Sims, Wassim Elyaman, , Marta Olah

The paper identifies microglia subsets in ALS brain and spinal cord, finding an undifferentiated phenotype and enrichment of interferon response microglia in aggressive cases.

Acta Neuropathologica · Jul 29, 2025Peer-reviewedNeuroscience

The Role of Alpha Synuclein in Synucleinopathy: Impact on Lipid Regulation at Mitochondria ER Membranes

Peter A. Barbuti, Cristina Guardia‐Laguarta, Taekyung Yun, Zena K. Chatila, Xena E. Flowers, Chantel Wong, Bruno F. R. Santos, Simone B. Larsen, James S. Lotti, Nobutaka Hattori, Elizabeth M. Bradshaw, Ulf Dettmer, Saranna Fanning, Vilas Menon, Hasini Reddy, , Serge Przedborski

This paper investigates the role of alpha-synuclein in lipid regulation at MAM domains in synucleinopathies, showing disease-specific lipid alterations and Syn's impact on phosphatidylserine metabolism.

npj Parkinson s Disease · Apr 30, 2025Peer-reviewedNeuroscience

RNA- and ATAC-sequencing Reveals a Unique CD83+ Microglial Population Focally Depleted in Parkinson's Disease

Zena K. Chatila, A. Yadav, J. Mares, Xena E. Flowers, Taekyung Yun, M. Rashid, Ryan Talcoff, Z. Pelly, Ya Zhang, Philip L. De Jager, Andrew F. Teich, Rui M. Costa, Estela Área-Gómez, G. Martins, Roy N. Alcalay, , Serge Przedborski

The paper uses single-nucleus RNA- and ATAC-sequencing to identify a CD83+ microglial subpopulation depleted in Parkinson's disease, with implications for neuronal vulnerability.

bioRxiv · May 17, 2023 · PreprintNeuroscience

Single nuclei RNAseq analysis of HD mouse models and human brain reveals impaired oligodendrocyte maturation and potential role for thiamine metabolism

Ryan G. Lim, Osama Al‐Dalahmah, Jie Wu, Maxwell P. Gold, Jack C. Reidling, Guomei Tang, Miriam Adam, David K. Dansu, Hye-Jin Park, Patrizia Casaccia, Ricardo Miramontes, Andrea M. Reyes-Ortiz, Alice Lau, Fatima Khan, Fahad Paryani, , Leslie Michels Thompson

This study uses snRNAseq to analyze HD mouse models and human brain tissue, identifying impaired oligodendrocyte maturation and a potential role for thiamine metabolism in disease pathology.

bioRxiv · Jun 27, 2022 · PreprintNeuroscience

Neuroinflammation characterizes the earliest changes in Alzheimer's disease pathology and associated subjective cognitive impairment in adult hydrocephalus biopsies

Wenrui Huang, Anne Marie W. Bartosch, Harrison Xiao, Xena E. Flowers, Sandra Leskinen, Zeljko Tomljanovic, Gail M. Iodice, Deborah M. Boyett, Eleonora F. Spinazzi, Vilas Menon, Robert A. McGovern, Guy M. McKhann, Andrew F. Teich

The paper identifies gene expression changes in Alzheimer's disease pathology linked to cognitive impairment in hydrocephalus biopsies, showing microglial activation and loss of homeostatic genes.

bioRxiv · Oct 1, 2020 · PreprintNeuroscience