TangentXY: Improved copy-number estimation of sex chromosomes reveals features associated with aneuploidies in chromosomes X and Y across cancers
Kei Enomoto, Shahab Sarmashghi, Sean A. Misek, Siyun Lee, Gregory Raskind, Stephanie H. Hoyt, Galen Gao, Davy Deng, Xiaomeng Zhang, Jérémie Kalfon, Gordon Saksena, Andrew D. Cherniack, Rameen Beroukhim
TangentXY improves copy-number estimation for sex chromosomes, revealing associations between chrX and chrY copy-number alterations and cancer features.
bioRxiv · Oct 2, 2026 · PreprintCancer Biology