Author

Siyun Lee

Broad InstituteORCID 0009-0005-5130-5212Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Rameen BeroukhimiD· 2 shared Alexander CraneiD· 1 shared Andrew D. CherniackiD· 1 shared Davy DengiD· 1 shared Frank P. B. DuboisiD· 1 shared Galen Gao· 1 shared Gordon SaksenaiD· 1 shared Gregory RaskindiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

Rameen BeroukhimORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintOct 2, 2026

TangentXY: Improved copy-number estimation of sex chromosomes reveals features associated with aneuploidies in chromosomes X and Y across cancers

Kei Enomoto, Shahab Sarmashghi, Sean A. Misek…·Rameen Beroukhim

TangentXY improves copy-number estimation for sex chromosomes, revealing associations between chrX and chrY copy-number alterations and cancer features.

DOI 10.64898/2026.10.01.755972

humanwhole-genome sequencing

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BioinformaticsbioRxivPreprintOct 9, 2023

Comparison of germline and somatic structural variants in cancers reveal systematic differences in variant generating and selection processes

Wolu Chukwu, Siyun Lee, Alexander Crane…·Simona Dalin

The paper compares germline and somatic structural variants in cancer, identifying differences in their generating processes and selection, and develops a classifier to distinguish them in tumor samples without matched normals.

2 citations

humanwhole-genome sequencing

𝕏 PostBluesky