Endothelial cells secreted ET-1 augments DN via inducing EM accumulation of MCs in ETBR-/- mice
Hong-hong Zou, Li Wang, Yun-feng Shen, Xiao-xu Zheng, Gao-si Xu
This study shows ET-1 secreted by endothelial cells in ETBR-/- mice worsens diabetic nephropathy by promoting mesangial cell proliferation and ECM accumulation through NF-kappaB and RhoA/ROCK pathways.
bioRxiv · Apr 18, 2018 · PreprintBiochemistry