Exploring the repository of de novo designed bifunctional antimicrobial peptides through deep learning
Ruihan Dong, Rongrong Liu, Ziyu Liu, Yangang Liu, Gaomei Zhao, Honglei Li, Shiyuan Hou, Xiaohan Ma, Huarui Kang, Jing Liu, Fei Guo, Ping Zhao, Junping Wang, Cheng Wang, Xingan Wu, , Cheng Zhu
This paper designs bifunctional antimicrobial peptides using deep learning, discovering 16 peptides with both antibacterial and antiviral activity, including two validated against drug-resistant bacteria and viruses.
eLife · Mar 13, 2025Peer-reviewedBioinformatics