Cheng Zhu

This study identifies a loop-dependent inhibitory mechanism in AcrIIC1 anti-CRISPR proteins, showing how a unique loop enhances inhibition by disrupting sgRNA binding and R-loop maturation.

This paper designs bifunctional antimicrobial peptides using deep learning, discovering 16 peptides with both antibacterial and antiviral activity, including two validated against drug-resistant bacteria and viruses.

This study shows capsaicin directly binds KEAP1 and allosterically activates NRF2, reducing ethanol-induced gastric oxidative damage and suggesting its potential as a novel NRF2 agonist for oxidative stress-related diseases.

The paper identifies Rep1 as a galactose sensor in Candida albicans that recruits Cga1 to activate GAL gene transcription, revealing a novel regulatory mechanism in fungal metabolism.