A second generation IL-2 receptor-targeted diphtheria fusion toxin exhibits anti-tumor activity and synergy with anti-PD-1 in melanoma
Laurene S. Cheung, Juan Fu, Pankaj Kumar, Amit Kumar, Michael E. Urbanowski, Elizabeth A. Ihms, Sadiya Parveen, C. Korin Bullen, Garrett Patrick, Robert Harrison, John R. Murphy, Drew M. Pardoll, William R. Bishai
This paper describes a second-generation diphtheria toxin-based fusion protein with reduced vascular leak and improved therapeutic activity in melanoma when used alone or with anti-PD-1.
bioRxiv · Sep 17, 2018 · PreprintCancer Biology