Spatial and longitudinal tracking of enhancer-AAV vectors that target transgene expression to injured mouse myocardium
David W. Wolfson, Joshua A. Hull, Yongwu Li, Trevor J. Gonzalez, Mourya D Jayaram, Garth W. Devlin, Valentina Cigliola, Kelsey A Oonk, Alan Rosales, Nenad Bursac, Aravind Asokan, Kenneth D. Poss
The paper tracks enhancer-AAV vector expression in injured mouse myocardium using bioluminescent imaging to evaluate spatial and temporal dynamics and identify improved capsids for targeted transgene delivery.
eLife · Sep 12, 2025Peer-reviewedDevelopmental Biology