Kenneth D. Poss

Asymmetric regeneration dynamics in zebrafish pectoral fins

This study quantifies spatial asymmetry in zebrafish pectoral fin regeneration, revealing differential gene expression and signaling dynamics between anterior and posterior regions.

Microenvironmental and transcriptional determinants of the robustness of spinal cord regeneration in zebrafish

The paper identifies hoxb5a as a critical regulator of spinal cord regeneration in zebrafish by analyzing transcriptional and microenvironmental differences between successful and failed regeneration cases.

Decaying and expanding Erk gradients process memory of skeletal size during zebrafish fin regeneration

The paper quantifies Erk signaling gradients in zebrafish fin regeneration and shows they scale with tissue amputation size to control skeletal regeneration.

Enhancer-directed gene delivery for digit regeneration based on conserved epidermal factors

This paper develops a gene therapy approach for digit regeneration using enhancer-directed delivery of FGF8 to restore impaired regeneration in SP transcription factor knockout mice.

Epicardial Tcf21 facilitates cardiomyocyte dedifferentiation and heart regeneration in zebrafish

This study investigates the role of Tcf21 in zebrafish heart regeneration by knocking out its expression and observing reduced cardiomyocyte dedifferentiation and impaired regeneration.

Live visualization of extracellular matrix dynamics during development and regeneration in zebrafish

The paper develops a method to visualize ECM dynamics in zebrafish during development and regeneration, revealing distinct expression patterns and dynamic behaviors of specific ECM proteins.

Buffering of genetic defects in animal development by regeneration programs

The paper identifies genetic mutations that affect regeneration programs in zebrafish, showing that these programs can buffer developmental defects.

Spatial and longitudinal tracking of enhancer-AAV vectors that target transgene expression to injured mouse myocardium

The paper tracks enhancer-AAV vector expression in injured mouse myocardium using bioluminescent imaging to evaluate spatial and temporal dynamics and identify improved capsids for targeted transgene delivery.

Phased ERK-responsiveness and developmental robustness regulate teleost skin morphogenesis

The paper studies ERK signaling dynamics in zebrafish periderm during axial elongation, finding stage-dependent responsiveness and developmental robustness.

The Translation Initiation Factor Homolog, eif4e1c, Regulates Cardiomyocyte Metabolism and Proliferation During Heart Regeneration

This study identifies eif4e1c's role in zebrafish heart development and regeneration by showing its impact on cardiomyocyte metabolism and proliferation through translation regulation.

Progenitor derived glia are required for spinal cord regeneration in zebrafish

This study identifies the role of progenitor-derived glia in zebrafish spinal cord regeneration through genetic and molecular analyses.

Identification of enhancer regulatory elements that direct epicardial gene expression during zebrafish heart regeneration

The paper identifies enhancer elements that regulate epicardial gene expression during zebrafish heart regeneration by analyzing transcriptomes and chromatin accessibility.

DeepProjection: Rapid and structure-specific projections of tissue sheets embedded in 3D microscopy stacks using deep learning

DeepProjection extracts high-resolution content from 3D microscopy stacks by masking background, enabling dynamic tracking of tissue sheets in developmental biology.

Mathematical modeling of Erk activity waves in regenerating zebrafish scales

The paper develops a reaction-diffusion model to explain Erk activity waves in zebrafish scale regeneration, showing how feedback loops control wave properties and propagation.

Generation of specialized blood vessels through transdifferentiation of lymphatic endothelial cells

This study shows that lymphatic endothelial cells can transdifferentiate into blood vessel endothelial cells in zebrafish, linking cell origin to function in vascular development and regeneration.

In vivo proximity labeling identifies cardiomyocyte protein networks during zebrafish heart regeneration

The paper uses BioID2 proximity labeling to identify cardiomyocyte protein networks during zebrafish heart regeneration and finds Rho A is a target of ErbB2 signaling involved in muscle creation.

Transgenic mice for in vivo epigenome editing with CRISPR-based systems

This paper describes the generation of two transgenic mouse lines for in vivo epigenome editing using CRISPR-based systems to activate or repress gene expression.

An Array of 60,000 Antibodies for Proteome-Scale Antibody Generation and Target Discovery

The paper develops PETAL, a library of 62,208 mAbs against 15,199 peptides, enabling proteome-scale antibody generation and target discovery across species.