Aravind Asokan

This paper develops a gene therapy approach for digit regeneration using enhancer-directed delivery of FGF8 to restore impaired regeneration in SP transcription factor knockout mice.

The paper tracks enhancer-AAV vector expression in injured mouse myocardium using bioluminescent imaging to evaluate spatial and temporal dynamics and identify improved capsids for targeted transgene delivery.

This study repurposes CRISPR-Cas13 systems to enable trans-splicing of exogenous RNA fragments into endogenous pre-mRNA, improving editing of large mRNA segments in mammalian cells.

The paper identifies MAAP as a novel AAV egress factor that facilitates secretion of AAV particles through Rab11+ vesicles and EV markers.

This paper describes the generation of two transgenic mouse lines for in vivo epigenome editing using CRISPR-based systems to activate or repress gene expression.

This study confirms that AQP4 is essential for glymphatic fluid and solute transport in the rodent brain, as Aqp4 disruption reduces CSF influx and amyloid-beta efflux.