Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1.
Nicolas J Lehrbach, Gary Ruvkun
This study identifies DDI-1 as a protease that cleaves and activates SKN-1A/Nrf1 in response to proteasome dysfunction, revealing a conserved mechanism across species.
bioRxiv · Jun 5, 2016Genetics