Gary Ruvkun

Lysosome-related organelle genes are required for mitochondrial transformations during bacterial infections in Caenorhabditis elegans.

This study shows that lysosome-related organelle genes are necessary for mitochondrial remodeling during bacterial infections in C. elegans and drive downstream infection-response gene expression.

The effects of intense light on Caenorhabditis elegans.

This study examines the effects of intense LED light on C. elegans, finding oxidative stress, mitochondrial damage, and shelter-seeking behavior, with LROs providing protection and canonical light receptors playing a dispensable role.

Caenorhabditis elegans SynMuv B gene activity is down-regulated during a viral infection to enhance RNA interference

The paper shows that reduced synMuv B gene activity in C. elegans enhances RNA interference against viral infection.

Hypoxia-inducible factor induces cysteine dioxygenase and promotes cysteine homeostasis in Caenorhabditis elegans

The paper identifies a feedback loop where high cysteine levels activate HIF-1 to induce cdo-1, promoting cysteine degradation via an H2S signaling pathway in C. elegans.

Phylogenetic evidence for asparagine to aspartic acid protein editing of N-glycosylated SARS-CoV-2 viral proteins by NGLY1 deglycosylation/deamidation suggests an unusual vaccination strategy

The paper suggests that viruses, including SARS-CoV-2, may use NGLY1/PNG-1 to edit N-glycosylated asparagines to aspartic acid, and proposes vaccinating with N to D edited viral peptides to enhance immunity.

Two isoforms of the essential C. elegans Argonaute CSR-1 differentially regulate sperm and oocyte fertility

The paper identifies two CSR-1 isoforms in C. elegans and shows they have distinct roles in fertility and immunity.

Protein-bound molybdenum cofactor is bioavailable and rescues molybdenum cofactor-deficient C. elegans

The paper shows that protein-bound molybdenum cofactor (Moco) is bioavailable and rescues Moco-deficient C. elegans, suggesting a new therapeutic strategy for human Moco deficiency.

Nanopore Sequencing at Mars, Europa and Microgravity Conditions

This study demonstrates nanopore sequencing functionality under reduced gravity conditions relevant to space exploration, including Mars and icy moons, showing consistent performance across different gravitational environments.

Induction of RNA interference by C. elegans mitochondrial dysfunction via the DRH-1/RIG-I homologue RNA helicase and the EOL-1/RNA decapping enzyme

This study shows that mitochondrial dysfunction in C. elegans activates RNAi through a pathway similar to the mammalian RIG-I response, involving DRH-1 and EOL-1, and contributes to increased longevity.

Caenorhabditis elegans ADAR editing and the ERI-6/7/MOV10 RNAi pathway silence endogenous viral elements and LTR retrotransposons

The paper identifies ADARs and the ERI-6/7/MOV10 RNAi pathway as factors silencing endogenous viral elements and LTR retrotransposons in C. elegans, with implications for genome integrity and stress responses.

Bacterial carotenoids suppress Caenorhabditis elegans surveillance and defense of translational dysfunction

This study identifies bacterial carotenoids as inhibitors of C. elegans translational surveillance and defense, with implications for human immune responses.

ROS-based lethality of C. elegans mitochondrial electron transport mutants grown on E. coli siderophore iron release mutants

The paper identifies E. coli mutations that induce a C. elegans mitochondrial damage response and finds four mutations disrupting iron handling in enterobactin are synthetic lethal with C. elegans mitochondrial mutants.

Nucleic acid extraction and sequencing from low-biomass synthetic Mars analog soils for in situ life detection

This study validates nucleic acid extraction and low-input nanopore sequencing from Mars analog soils to detect genetic sequences indicative of potential life on Mars.

CarrierSeq: a sequence analysis workflow for low-input nanopore sequencing

CarrierSeq identifies low-input target reads from nanopore sequencing by filtering out contamination and noise using a statistical test based on channel-specific read patterns.