Histone H1 Promotes Silencing of Unintegrated HIV-1 DNA
Jiaqi Zhu, Gary Z. Wang, Hugo Borges Pinto, Sean E. Healton, Laxmi N. Mishra, Arthur I. Skoultchi, Stephen P. Goff
This study shows that H1 histone variants suppress HIV-1 but not MLV unintegrated DNA transcription in K562 cells by reversing silencing.
Proceedings of the National Academy of Sciences · Jul 1, 2026Peer-reviewedMicrobiology