Author

Hugo Borges Pinto

Albert Einstein College of MedicineORCID 0000-0002-6970-4693Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Developmental Biology· 1 Genomics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:ChIP-seq· 4 Approach:experimental assay· 4 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Organism:human· 3 Research Focus:chromatin & epigenetic regulation· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Arthur I. SkoultchiiD· 4 shared Dmitry V. FyodoroviD· 2 shared Andrés MansisidoriD· 1 shared Andrew Scortea· 1 shared Ankita SahaiD· 1 shared Arnold OuiD· 1 shared Bruna Mafra de Faria· 1 shared Charles C. QueryiD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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4 shared papersMicrobiology

Arthur I. SkoultchiORCID

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Author profile →

4 papers

Recent·Most cited

Histone H1 Promotes Silencing of Unintegrated HIV-1 DNA

Jiaqi Zhu, Gary Z. Wang, Hugo Borges Pinto, Sean E. Healton, Laxmi N. Mishra, Arthur I. Skoultchi, Stephen P. Goff

This study shows that H1 histone variants suppress HIV-1 but not MLV unintegrated DNA transcription in K562 cells by reversing silencing.

Proceedings of the National Academy of Sciences · Jul 1, 2026Peer-reviewedMicrobiology

Direct measurement of sub-kilobase chromatin structure reveals that linker histone H1 broadly compacts chromatin, with differential impact amongst epigenetic states

Hera Canaj, Irene Duba, Andrés Mansisidor, Andrew Scortea, Ryan Johnson, Hugo Borges Pinto, Arnold Ou, Nicole Pagane, Juhee Pae, Dmitry V. Fyodorov, Arthur I. Skoultchi, Viviana I. Risca

The paper directly measures sub-kilobase chromatin structure using RICC-seq 2.0 and finds that linker histone H1 broadly compacts chromatin, with differential effects on gene expression and epigenetic states.

bioRxiv · Dec 23, 2025 · PreprintGenomics

Linker histone regulates the myeloid versus lymphoid bifurcation of multipotent hematopoietic stem and progenitors

Kutay Karatepe, Bruna Mafra de Faria, Jian Zhang, Xinyue Chen, Hugo Borges Pinto, Dmitry V. Fyodorov, Esen Sefik, Michael A. Willcockson, Richard Anthony Flavell, Arthur I. Skoultchi, Shangqin Guo

This study shows that linker histone H1.0 regulates HSPC fate bias toward lymphoid or myeloid differentiation, with H1.0 levels decreasing in response to IFN signaling.

Proceedings of the National Academy of Sciences · Oct 21, 2025Peer-reviewedDevelopmental Biology

PRMT5 activity sustains histone production to maintain genome integrity

Jacob S. Roth, Joseph D. DeAngelo, Dejauwne L. Young, Maxim I. Maron, Ankita Saha, Hugo Borges Pinto, Varun Gupta, Noah Jacobs, Subray S. Hegde, Jennifer T. Aguilan, Joel Basken, Joey Azofeifa, Charles C. Query, Simone Sidoli, Arthur I. Skoultchi, David Shechter

This study shows PRMT5 sustains histone transcription and protein synthesis during S phase, maintaining genome integrity by regulating histone H4 methylation.

bioRxiv · Jul 3, 2025 · PreprintCell Biology