An in vivo platform to jointly monitor cellular and metabolic responses to chemotherapy.
Veronika I. Pister, Zuzana Tatárová, Noel R. Park, Gautami Gaidhani, Juraj Jakubík, Laura M. Heiser, Jenna Lynn Elizabeth Blum, Alec Palmiotti, Ellen Maloney, Ernest Fraenkel, Shawn M. Davidson, Oliver H. Jonas
The paper introduces a spatial pharmacology platform to study how chemotherapy affects immune and metabolic states in tumors, identifying key metabolic axes and resistant macrophage populations.
bioRxiv · Jun 26, 2026 · PreprintBioengineering