Jenna L. E. Blum

This study maps spatial metabolic activity in adult fruit flies using isotope tracing and mass-spectrometry imaging, revealing compartmentalized nutrient use across tissues.

The paper introduces a spatial pharmacology platform to study how chemotherapy affects immune and metabolic states in tumors, identifying key metabolic axes and resistant macrophage populations.

This study maps metabolic changes in 12 organs of male and female mice across 5 ages, identifying sex-specific patterns and a metabolic aging clock.

The paper identifies age-related microbiome metabolites that alter RNA splicing and chromatin accessibility in the mouse brain using metabolomics, transcriptomic, and multi-omic approaches.

This study shows metformin lowers blood glucose by inhibiting intestinal mitochondrial complex I, increasing lactate and GDF15, and promoting glucose uptake.

This study shows that increasing mitochondrial NAD+ regeneration via MitoLbNOX does not rescue dopaminergic neuron dysfunction caused by complex I impairment in Parkinson's disease mice.