Shawn M. Davidson

Spatial isotope tracing maps compartmentalized nutrient use across the adult fruit fly

This study maps spatial metabolic activity in adult fruit flies using isotope tracing and mass-spectrometry imaging, revealing compartmentalized nutrient use across tissues.

An in vivo platform to jointly monitor cellular and metabolic responses to chemotherapy.

The paper introduces a spatial pharmacology platform to study how chemotherapy affects immune and metabolic states in tumors, identifying key metabolic axes and resistant macrophage populations.

A metabolic atlas of mouse aging

This study maps metabolic changes in 12 organs of male and female mice across 5 ages, identifying sex-specific patterns and a metabolic aging clock.

Age-related microbiome metabolites alter RNA splicing and chromatin accessibility in the brain

The paper identifies age-related microbiome metabolites that alter RNA splicing and chromatin accessibility in the mouse brain using metabolomics, transcriptomic, and multi-omic approaches.

Metformin inhibits mitochondrial complex I in intestinal epithelium to promote glycemic control

This study shows metformin lowers blood glucose by inhibiting intestinal mitochondrial complex I, increasing lactate and GDF15, and promoting glucose uptake.

Genetic modulation of mitochondrial NAD+ regeneration does not prevent dopaminergic neuron dysfunction caused by mitochondrial complex I impairment

This study shows that increasing mitochondrial NAD+ regeneration via MitoLbNOX does not rescue dopaminergic neuron dysfunction caused by complex I impairment in Parkinson's disease mice.

Loss of mitochondrial enzyme GPT2 leads to reprogramming of synaptic glutamate metabolism

This study shows that loss of GPT2 in mice disrupts glutamate metabolism and synaptic transmission, with rescue by alpha-ketoglutarate supplementation.

Multi-OMIC analysis of Huntington disease reveals a neuroprotective astrocyte state

This study uses multi-omic analysis to identify a neuroprotective astrocyte state in Huntington disease that correlates with delayed disease onset and neuroprotection.

Hormonal gatekeeping via the blood brain barrier governs behavior

The paper shows the blood-brain barrier regulates social behavior in ants by controlling hormone levels via a key enzyme, with implications for conserved mechanisms across species.

Single nuclei RNAseq analysis of HD mouse models and human brain reveals impaired oligodendrocyte maturation and potential role for thiamine metabolism

This study uses snRNAseq to analyze HD mouse models and human brain tissue, identifying impaired oligodendrocyte maturation and a potential role for thiamine metabolism in disease pathology.