A refined sticker-spacer grammar marks disordered regions with interpretable pathogenic missense variation
Gavin E Remo, Gabriel A Andaverde, Karen A. Lewis, Loren E. Hough, Steven T. Whitten
The paper identifies a refined sticker-spacer grammar in phase-separating IDRs that correlates with pathogenic missense variants and explains mutational vulnerability in disordered proteins.
bioRxiv · Sep 30, 2026 · PreprintBiophysics