Karen A. Lewis

The paper shows that telomerase elongates a second substrate formed by spontaneous replication fork collapse in budding yeast, significantly contributing to telomere length homeostasis.

The paper identifies a refined sticker-spacer grammar in phase-separating IDRs that correlates with pathogenic missense variants and explains mutational vulnerability in disordered proteins.

The paper links missense mutations in intrinsically disordered regions (IDRs) to disease by showing their association with phase separation and identifying specific amino acid substitutions that increase pathogenicity.