Steven T. Whitten

The paper identifies a refined sticker-spacer grammar in phase-separating IDRs that correlates with pathogenic missense variants and explains mutational vulnerability in disordered proteins.

The paper links missense mutations in intrinsically disordered regions (IDRs) to disease by showing their association with phase separation and identifying specific amino acid substitutions that increase pathogenicity.

This study examines how different crowding agents affect the aggregation of an FG nucleoporin peptide, revealing variations in kinetics and residue microenvironment.