Loren E. Hough

A refined sticker-spacer grammar marks disordered regions with interpretable pathogenic missense variation

The paper identifies a refined sticker-spacer grammar in phase-separating IDRs that correlates with pathogenic missense variants and explains mutational vulnerability in disordered proteins.

Tubulin C-terminal tails are pH sensors that regulate microtubule function

The paper investigates how tubulin C-terminal tails respond to pH changes and shows their role in regulating microtubule interactions through protonation of glutamate residues.

Nonspecific interactions can lead to liquid-liquid phase separation in coiled-coil proteins models

The paper shows that nonspecific interactions in coiled-coil proteins can lead to liquid-liquid phase separation, and that linker segments can enhance this process without altering interaction specificity.

Missense mutations in intrinsically disordered protein regions link pathogenicity and phase separation

The paper links missense mutations in intrinsically disordered regions (IDRs) to disease by showing their association with phase separation and identifying specific amino acid substitutions that increase pathogenicity.

Biophysical characterization of high-confidence, small human proteins

The paper characterizes biophysical properties of small human proteins, finding significant differences compared to larger proteins and providing insights for distinguishing functional from non-coding small open reading frames.

Aggregation of an FG nucleoporin under crowded conditions

This study examines how different crowding agents affect the aggregation of an FG nucleoporin peptide, revealing variations in kinetics and residue microenvironment.