Empirical evidence for heterozygote advantage in adapting diploid populations of Saccharomyces cerevisiae
Diamantis Sellis, Daniel J Kvitek, Barbara Dunn, Gavin Sherlock, Dmitri A Petrov
The paper shows that overdominant mutations are common in adaptive evolution of diploid yeast, supporting the idea that heterozygote advantage can arise from directional selection.
bioRxiv · Dec 2, 2015Evolutionary Biology