Dmitri A Petrov

A genotype-phenotype-fitness map reveals local modularity and global pleiotropy of adaptation

The paper maps genotype-phenotype-fitness relationships in yeast to show local modularity and global pleiotropy of adaptive mutations.

Whole Genome Analysis of 132 Clinical Saccharomyces cerevisiae Strains Reveals Extensive Ploidy Variation

The paper analyzes whole-genome data from 132 clinical Saccharomyces cerevisiae strains to show extensive ploidy and aneuploidy variation, linking these genomic changes to adaptive processes.

Empirical evidence for heterozygote advantage in adapting diploid populations of Saccharomyces cerevisiae

The paper shows that overdominant mutations are common in adaptive evolution of diploid yeast, supporting the idea that heterozygote advantage can arise from directional selection.

Viruses are a dominant driver of protein adaptation in mammals

This study shows viruses drive significant protein adaptation in mammals, affecting both immune and non-immune functions across many proteins.

More efficacious drugs lead to harder selective sweeps in the evolution of drug resistance in HIV-1

The paper shows that more effective HIV drugs lead to harder selective sweeps in drug resistance evolution, as evidenced by analyzing HIV-1 sequences over time.

Illumina TruSeq synthetic long-reads empower de novo assembly and resolve complex, highly repetitive transposable elements

This study uses TruSeq synthetic long-reads to improve de novo genome assembly, particularly resolving complex transposable elements in Drosophila melanogaster.