CLM296: a highly selective inhibitor targeting ALDH1A3-driven tumor growth and metastasis in breast cancer
Maya R. MacLean, Bianca Laura Bernardoni, Wasundara Fernando, Giovanni Petrarolo, Ilaria D’Agostino, Cheryl A. Dean, Jaganathan Venkatesh, Christopher S. Hughes, Kerry B. Goralski, Geetha Subramanian, Raj Pranap Arun, Hannah F. Cahill, Olivia L. Walker, Concettina La Motta, Paola Marcato
This paper introduces CLM296, a highly selective ALDH1A3 inhibitor that reduces tumor growth and metastasis in TNBC xenografts with favorable pharmacokinetics and safety profile.
bioRxiv · Apr 16, 2025 · PreprintCancer Biology