DNA methylation maintenance by DNMT1 is essential for human trophoblast stem cell homeostasis and differentiation
Sanam L. Kavari, Yu Jin Jang, Gena D. Guerin, Laurel S Park, Elisia D. Tichy, Joonhyuk Choi, Jonghwan Kim, Winifred Mak, Jennifer M. Kalish
This study shows that DNMT1 is crucial for human trophoblast stem cell proliferation, differentiation, and DNA methylation, linking its dysfunction to recurrent pregnancy loss.
bioRxiv · Jul 3, 2026 · PreprintDevelopmental Biology