Winifred Mak

The paper identifies AluY epimutations in sperm from men with unexplained recurrent pregnancy loss, showing they are enriched in hypomethylated regions and linked to genes involved in early development.

This study shows that DNMT1 is crucial for human trophoblast stem cell proliferation, differentiation, and DNA methylation, linking its dysfunction to recurrent pregnancy loss.

This study uses whole-exome sequencing on products of conception to identify genetic causes of pregnancy loss, finding pathogenic variants in 22% of cases and a higher rate with uncertain variants included.

This study identifies distinct roles of Pum1 and Pum2 in ESC pluripotency and embryogenesis, revealing novel post-transcriptional regulatory mechanisms.