Exploring protein orthogonality in immune space: a case study with AAV and Cas9 orthologs
Ana M. Moreno, Nathan D. Palmer, Fernando Alemán, Genghao Chen, Andrew Pla, Wei Leong Chew, Mansun Law, Prashant Mali
The paper explores immune orthogonality among protein orthologs by analyzing CRISPR-Cas9 and AAV serotypes, finding high immune orthogonality in Cas9 but not in AAVs.
bioRxiv · Jan 10, 2018 · PreprintSynthetic Biology