Author

Andrew Pla

University of California San Diego

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Genomics· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Ana M. MorenoiD· 2 shared Fernando AlemániD· 2 shared Prashant MaliiD· 2 shared Cagdas Tazearslan· 1 shared Danielle SookiasianiD· 1 shared Genghao Chen· 1 shared Glaucilene Ferreira CatroliiD· 1 shared Gustavo Cerqueira· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersGenetics

Ana M. MorenoORCID

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3 papers

Recent·Most cited

Genome-wide assays to characterize rAAV integration into human genomic DNA in vivo

Jaime Prout, Jessica R. Von Stetina, Gustavo Cerqueira, Madison Chasse, Huei-Mei Chen, Andrew Pla, Rachel Resendes, Danielle Sookiasian, Cagdas Tazearslan, Jason B. Wright, John F. Thompson

The paper develops long-read sequencing assays to detect on- and off-target integration of rAAV vectors in human genomic DNA, finding no evidence of off-target integration.

bioRxiv · Aug 22, 2023 · PreprintGenomics

Long-lasting Analgesia via Targeted in vivo Epigenetic Repression of Nav1.7

Ana M. Moreno, Glaucilene Ferreira Catroli, Fernando Alemán, Andrew Pla, Sarah A. Woller, Michael Y. Hu, Tony L. Yaksh, Prashant Mali

This study develops a method to achieve long-lasting, non-addictive pain relief by epigenetically repressing NaV1.7 in vivo using CRISPR-dCas9 and zinc finger proteins.

bioRxiv · Jul 24, 2019 · PreprintGenetics

Exploring protein orthogonality in immune space: a case study with AAV and Cas9 orthologs

Ana M. Moreno, Nathan D. Palmer, Fernando Alemán, Genghao Chen, Andrew Pla, Wei Leong Chew, Mansun Law, Prashant Mali

The paper explores immune orthogonality among protein orthologs by analyzing CRISPR-Cas9 and AAV serotypes, finding high immune orthogonality in Cas9 but not in AAVs.

bioRxiv · Jan 10, 2018 · PreprintSynthetic Biology