Analogs of the Dopamine Metabolite 5,6-Dihydroxyindole Bind Directly to and Activate the Nuclear Receptor Nurr1 (NR4A2)
Svetlana A. Kholodar, Geoffrey Lang, Wilian Augusto Cortopassi, Yoshie Iizuka, Harman Brah, Matthew P. Jacobson, Pamela M. England
The paper identifies 5-chloroindole as a stable analog of DHI that activates Nurr1 and promotes dopamine-related gene transcription.
ACS Chemical Biology · Jun 24, 2021Peer-reviewedNeuroscience